Members of the caspase family play key roles in inflammation and mammalian apoptosis. Z-VAD-FMK, a molecular weight of 467 Daltons, is a cell permeable general caspase inhibitor that irreversibly binds to the catalytic site of caspase proteases and inhibits apoptosis.
Store undiluted at -20°C. Reconstitute the substrate before use. Reconstitute in 1 ml DMSO to yield 1 mg/ml peptide in DMSO. Store the reconstituted substrate at –20°C for up to 1-2 months and avoid repeated freeze-thaw cycles.
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