Alpha-1-Antichymotrypsin (ACT) is an early-stage acute phase protein and a member of the serine proteinase inhibitor or serpin superfamily. The precise role of ACT is uncertain but it is thought to act as an anti-inflammatory agent inhibiting chymotrypsin, cathepsin G, mast cell chymase, neutrophil chemotaxis and superoxide anion production. ACT is synthesized primarily by hepatocytes of the liver. Lower levels of synthesis have also been discovered via immunohistochemical analysis in mast cells, endothelial cells, breast and intestinal epithelial cells. ACT also exists in the brain. Research has shown that it is found in amyloid fibrils, endothelial cells and the cytoplasm of astroglial cells in certain brain abnormalities. Further research has also shown that a major proportion of prostate-specific antigen (PSA) in serum exists complexed to ACT.
KIT COMPONENTS (100 reactions)
- 50x DAB Chromogen 1 x 0.5ml
- Biotinylated goat anti-rabbit IgG(H+L) 1 x 15ml
- DAB substrate 1 x 15ml
- Hydrogen Peroxide Block 1 x 15ml
- Protein block 1 x 15ml
- Streptavidin Peroxidase 1 x 15ml
- Rabbit anti-human ACT 1 X 15ml
Store at +4°C. Please refer to protocols.
The products is “FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES”