Tau is important in establishing and maintaining neuronal morphology and is a major component of the neurofibrillary tangles (NFTs) characteristic of an Alzheimer’s diseased brain. Tau is also expressed in epithelial cells, including breast tissue. Down-regulation of Tau expression in breast cancer cells increases sensitivity to paclitaxel. Tau may be used as a marker to select patients for paclitaxel therapy. High Tau expression in estrogen receptor (ER)-positive breast cancer indicates an endocrine-sensitive but chemotherapy-resistant disease. In contrast, low Tau expression identifies a subset of ER-positive cancers that have poor prognosis with tamoxifen alone and may benefit from taxane-containing hemotherapy.
KIT COMPONENTS (100 reactions)
- 50x DAB Chromogen 1 x 0.5ml
- Biotinylated goat anti-rabbit IgG(H+L) 1 x 15ml
- DAB substrate 1 x 15ml
- Hydrogen Peroxide Block 1 x 15ml
- Protein block 1 x 15ml
- Streptavidin Peroxidase 1 x 15ml
- Rabbit anti-human Tau
Store at +4°C. Please refer to protocols.
The products is “”FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES”””